Crosslinking Reagents
Cayman Chemical PhytnIc AcId 50mg
An internal standard for the quantification of ethoprop by GC- or LC-MS
Cayman Chemical DocosatrIenoIc AcId 50mg
An antiviral nucleoside analog inhibits viral plaque formation and viral RNA synthesis in vaccinia virus-infected Vero cells at 10 UM
Cayman Chemical CaffeIc AcId methyl ester 50mg
A broad-spectrum antibiotic that inhibits protein synthesis by inducing miscoding commonly used as a dominant selection antibiotic for genetically modified bacteria yeasts fungi protozoa plants and mammalian cells
Cayman Chemical DIsuccInImIdyl Suberate 250mg
A potent inhibitor of DGAT-1 (IC50s 7 and 24 nM for human and mouse respectively) confers significant weight loss within seven days and significantly reduces plasma and liver triglycerides when administered at 3 mg/kg to DIO mice
Cayman Chemical Latnoprostfree acId 50mg
Selectively and reversibly blocks the CFTR channel (Ki 4.3 UM) reduces intestinal fluid secretion induced by cholera toxin effective in cells in culture and also in nasal and intestinal epithelia in vivo
Cayman Chemical 4-amIno-1 8-NaphthalImIde 50mg
A major epidermal chromophore for the immunosuppressive effects of UV radiation that is produced in mammalian stratum corneum by the action of L-histidine ammonia lyase on histidine
Cayman Chemical EZ-4-hydroxy TamoxIfen 50mg
A cell-permeable porphyrin derivative that selectively binds STAT3 (Kd 880 nM) inhibits STAT3 dimerization via Src homology 2 (Sh2) domains (IC50 280 nM) preventing nuclear translocation and DNA binding
Cayman Chemical 4-PyrIdoxIc AcId 50mg
An OAT1 inhibitor (IC50 25 UM in opossum kidney cells) increases the production of free radicals in opossum kidney cells expressing human OAT1 reduces the secretion of TNF-a by 30.4 at 1 UM
Cayman Chemical LNgchaIn Faty AcId Methyl 50mg
A lignan inhibits formation of AGEs in vitro decreases escape latency in the Morris water maze and increases spontaneous alternation in the Y-maze in a mouse model of Alzheimers disease induced by amyloid-B (1-42) at 0 1 mg/kg increases glial expression of GLP-1 and decreases immobility time in the FST in mice increases spontaneous alternation in the Y-maze in a mouse model of stress-induced short-term learning impairment induced by the FST
Cayman Chemical GInkgonlIc AcId 50mg
A dopamine metabolite levels are increased 5- to 6-fold compared to wild-type in the nucleus accumbens striatum and prefrontal cortex of COMT knockout mice oxidized DOPAC binds to monomeric a-synuclein preventing fibrillation foot shock stress increases levels relative to control in the prefrontal cortex olfactory tubercles and VTA in rats
Cayman Chemical Sulfosuccinimidyl 3-[[2- Biot
A vasopressin V1A receptor agonist selectively induces reporter gene expression in HEK293 cells expressing vasopressin V1A and V2 receptors in reporter assays (EC50s 0.69 and 0.45 nM respectively for the human receptors) over cells expressing vasopressin V1B receptors selective for vasopressin V1A and V2 receptors over the vasopressin V1B receptor and oxytocin receptor (EC50s 7.5 and 71 nM respectively) increases arterial blood pressure in rats at 0.1 nmol/kg
Cayman Chemical 12-TrIdecenoIc AcId 50mg
A Y-secretase inhibitor selectively cleaves APP CTF over Notch-1 CTF in HEK293 cells (IC50s 7.1 and 105.9 nM respectively) reduces increases in AB42 levels induced by AB (25-35) in the mouse hippocampus at 0.1-1 nmol/animal prevents deficits induced by AB (25-35) in the novel object recognition test when tested with a one-hour but not a 24-hour intertrial interval
Cayman Chemical 1S 3R3BenzoIc acId 3carb 50mg
An internal standard for the quantification of HPA by GC- or LC-MS
Cayman Chemical SulfosuccInImIdyl MyrIstAT 5mg
A cell-permeable reversible inhibitor of several kinases including PKCa PKCB PKCY Syk FLK1 AktPKA c-Kit C-Fgr c-Src FLT3 PDFRB VEGFR1 and VEGF2 with IC50 values ranging from 80-500 nM
Cayman Chemical SulfosuccInImIdyl OleATsod 5mg
A cell-permeable reversible inhibitor of several kinases including PKCa PKCB PKCY Syk FLK1 AktPKA c-Kit C-Fgr c-Src FLT3 PDFRB VEGFR1 and VEGF2 with IC50 values ranging from 80-500 nM